Mis queridossssss.... va a comenzar a dar revuelo el tema de la curacion del HIV en un paciente en Berlin. Bueno, no le di mucha bolilla hasta que vi una publicacion oficial en una revista medica creible (Blood, la revista de la American society of hematology) que lo publicaba en un Abstract.
Va el abstract in inglish y explicado en criollo abajo:
Evidence for the cure of HIV infection by CCR5{Delta}32/{Delta}32 stem cell transplantation
Kristina Allers1,*, Gero Hütter2, Jörg Hofmann3, Christoph Loddenkemper4, Kathrin Rieger2, Eckhard Thiel2 and Thomas Schneider1
1 Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany; 2 Department of Hematology, Oncology, and Transfusion Medicine, Medical Clinic III, Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany; 3 Institute of Medical Virology, Helmut-Ruska-Haus, Campus Mitte, Charite - University Medicine Berlin, Germany; 4 Institute of Pathology/Research Center ImmunoSciences (RCIS), Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany
Abstract
HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5{Delta}32/{Delta}32 stem cells. However, it was expected that the long-lived viral reservoir would lead to HIV rebound and disease progression during the process of immune reconstitution. In the present study, we demonstrate successful reconstitution of CD4+ T cells at the systemic level as well as in the gut mucosal immune system following CCR5{Delta}32/{Delta}32 stem cell transplantation, while the patient remains without any sign of HIV infection. This was observed although recovered CD4+ T cells contain a high proportion of activated memory CD4+ T cells, i.e. the preferential targets of HIV, and are susceptible to productive infection with CXCR4-tropic HIV. Furthermore, during the process of immune reconstitution, we found evidence for the replacement of long-lived host tissue cells with donor-derived cells indicating that the size of the viral reservoir has been reduced over time. In conclusion, our results strongly suggest that cure of HIV has been achieved in this patient.
Explicación en taringuero básico:
El flaco tenia HIV, con la medicación antirretroviral el cuadro estaba contenido, es decir, con baja carga viral y sin manifestaciones de SIDA. Se ligo una leucemia ("no te hagas mala sangre", le decian los médicos ), asi que decidieron hacerle un transplante. Lo inmunosuprimen al mango (le liquidan todas las defensas para que el cuerpo acepte el transplante y no lo ataque reconociendolo como agresor externo) y le transplantan nuevas células madre para que forme linfocitos sanos. Supusieron que el reservorio de células infectadas con HIV al replicarse los nuevos linfocitos T los infectarian, pero oh sorpresa, esto no ocurrió, no presentando el paciente hasta el momento signos de infección, lo que sugiere fuertemente que se haya curado.
Hay que ser cautos y pacientes, esto fue una suceción de hechos fortuitos.... pero en la medicina usualmente asi es como se llega a los descubrimientos mas trascendentales.
Salu2, Dr. Medu
Va el abstract in inglish y explicado en criollo abajo:
Evidence for the cure of HIV infection by CCR5{Delta}32/{Delta}32 stem cell transplantation
Kristina Allers1,*, Gero Hütter2, Jörg Hofmann3, Christoph Loddenkemper4, Kathrin Rieger2, Eckhard Thiel2 and Thomas Schneider1
1 Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany; 2 Department of Hematology, Oncology, and Transfusion Medicine, Medical Clinic III, Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany; 3 Institute of Medical Virology, Helmut-Ruska-Haus, Campus Mitte, Charite - University Medicine Berlin, Germany; 4 Institute of Pathology/Research Center ImmunoSciences (RCIS), Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany
Abstract
HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5{Delta}32/{Delta}32 stem cells. However, it was expected that the long-lived viral reservoir would lead to HIV rebound and disease progression during the process of immune reconstitution. In the present study, we demonstrate successful reconstitution of CD4+ T cells at the systemic level as well as in the gut mucosal immune system following CCR5{Delta}32/{Delta}32 stem cell transplantation, while the patient remains without any sign of HIV infection. This was observed although recovered CD4+ T cells contain a high proportion of activated memory CD4+ T cells, i.e. the preferential targets of HIV, and are susceptible to productive infection with CXCR4-tropic HIV. Furthermore, during the process of immune reconstitution, we found evidence for the replacement of long-lived host tissue cells with donor-derived cells indicating that the size of the viral reservoir has been reduced over time. In conclusion, our results strongly suggest that cure of HIV has been achieved in this patient.
Explicación en taringuero básico:
El flaco tenia HIV, con la medicación antirretroviral el cuadro estaba contenido, es decir, con baja carga viral y sin manifestaciones de SIDA. Se ligo una leucemia ("no te hagas mala sangre", le decian los médicos ), asi que decidieron hacerle un transplante. Lo inmunosuprimen al mango (le liquidan todas las defensas para que el cuerpo acepte el transplante y no lo ataque reconociendolo como agresor externo) y le transplantan nuevas células madre para que forme linfocitos sanos. Supusieron que el reservorio de células infectadas con HIV al replicarse los nuevos linfocitos T los infectarian, pero oh sorpresa, esto no ocurrió, no presentando el paciente hasta el momento signos de infección, lo que sugiere fuertemente que se haya curado.
Hay que ser cautos y pacientes, esto fue una suceción de hechos fortuitos.... pero en la medicina usualmente asi es como se llega a los descubrimientos mas trascendentales.
Salu2, Dr. Medu